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See 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) Circulation bloodborne versus tissue, 61 definition of, 61 role in uncertain drug retort, 62 amount of distribution, 63 DNA adducts effects on understudy helix dependability, 233 shape nearby 4-aminobiphenyl, 308 generation by aristolochic acid, 250 formation by epoxy 1,3-butadiene, 310 composition via genotoxic carcinogens, 232 materialization nearby PAH in smokers, 301 formation not later than vinyl chloride, 248 accumulation during the bottle revelation, 267 institution from acrolein in smokers, 297 formation via endogenous pathways, 240 multiplicity of routes to guanine adduction in smokers, 310 pyridyloxobutyl DNA adducts in smokers, 305 quantitation sooner than postlabelling, 240 throwing out via NER, 238 repair mechanisms, 236 rвЂњle in apoptosis induction, 238 reflect on via site-sepecific mutagenesis, 235 synthesis of adducted oligodeoxynucleotides, 232 DNA glycosylases, task in base excision repair, 238 DNA polymerases, role in evolving induction, 234 DNA patch adduct reverse (e. 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